You know how you're not supposed to stick anything in your ear smaller than your elbow? There's a reason for that: The little fancy holes on the side of our heads are precision instruments, more complex and precise than a Swiss clock.

The job of an ear is to provide balance and hearing, which is just a nifty little bit of auditory transduction — the conversion of sound waves (basically air molecules clacking together through space) into electrical signals we can process and understand. It turns out that's pretty complex. It's so complex, in fact, that scientists have never really been able to pinpoint what allows this complicated conversion to happen.

Transduction in other sensory systems has been well understood for decades, but because the inner ear is difficult to reach, there are comparatively few inner ear receptor cells to study (the inner ear has about 16,000 receptor cells compared to the human retina's 100,000), and the environment inside the cochlea — the shell-shaped cavity that houses all the tiny, hair-like receptor cells — is so delicate, it's a difficult experimentation subject.

But now a paper published Aug. 22, 2018, in the journal Neuron reports the unraveling of the mystery behind the "holy grail" of hearing proteins. The research team from Harvard Medical School has worked out that TMC1, a protein discovered back in 2002, is ultimately responsible for hearing and balance in vertebrates.

"We believe our findings settle that issue for good and yield definitive proof that TMC1 is the critical molecular sensor that converts sound and motion into electrical signals the brain can understand," said co-author Jeffrey Holt, Harvard Medical School professor of otolaryngology and neurology at Boston Children's Hospital, in a press release. "It is, indeed, the gatekeeper of hearing."


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